Two significantly similar cars, no doubt about that. Still, each one has something different to offer. Having both cars powered by petrol engines and utilizing the 4-door sedan body style within the same 'Luxury car' segment, the only major difference here really is their wheel drive configuration (rear for the Mercedes Benz and 4 x 4 in the case of the Audi). The first one has a Mercedes Benz-engineered powertrain under the hood, a 6-cylinder, 24-valves 252hp unit, while the other one gets its power and torque from a 8-cylinder, 32-valves 420hp engine designed by Volkswagen.

A starting point here would be to take a look at the results from European New Car Assessment Programme (Euro NCAP) tests which were performed on both of the cars, with the same number of safety stars gained in the process. That aside, let's consider some other aspects which affect safety. Both vehicles belong to the luxury car segment, which is generally a very good thing safety-wise, but it doesn't do much to help us decide between the two. On the other hand, if we'd like to consider vehicle mass in this context too, which we definitely should, Audi A6 offers a considerable difference of 15% more metal.

Reliability is not the best thing to consider on the make level, but it is worth mentioning that both brands display similar results in faults and breakdowns, all the models observed together. These are the results of an independent reasearch, while our visitors describe reliability of Mercedes Benz with an average rating of 4.4, and models under the Audi badge with 4.2 out of 5. Independent research findings rank E as average reliability-wise, and A6 is more or less at the same level.We should definitely mention that owners of cars with the same powertrain as Mercedes Benz E rank it on average as 3.0 out of 5, exactly the same as the other one.

Audi is undoubtly more agile, reaching 100km/h in 2.5 seconds less than its competitor. In addition to that it accelerates all the way to 250 kilometers per hour, exactly the same as the other car does. When it comes to fuel economy an obvious choice would be Mercedes Benz E, averaging around 6.8 liters of fuel per 100 kilometers (42 mpg), in combined cycle. That's 41% difference compared to Audi A6!

Mercedes Benz appears just a bit more reliable, although the difference is truly marginal. The most important thing when deciding between any two vehicles should always be safety, both passive and active. In my opinion, everything taken into account, Audi A6 offers significantly better overall protection, taking the lead here. It all continues in the same direction, with Audi being considerably quicker, thus putting more smile on driver's face. It does come at a cost though, and that's the fuel consumption... No mistake, whatever you decide here, but I'd still go for the Mercedes Benz. Nevertheless, let's not forget that people have different preferences and needs, so what really counts is your personal feel. I'm only here to help. I suggest you spend two more minutes in order to find out which car, based on your needs and budget, would be picked by the virtual adviser™, among thousands of similar, yet so different vehicles.