Two significantly similar cars, no doubt about that. Still, each one has something different to offer. Having both cars powered by petrol engines and utilizing the 4-door sedan body style within the same 'Luxury car' segment, the only major difference here really is their wheel drive configuration (4 x 4 for the Mercedes Benz and rear in the case of the Lexus). The first one has a Mercedes Benz-engineered powertrain under the hood, a 8-cylinder, 32-valves 388hp unit, while the other one gets its power and torque from a 8-cylinder, 32-valves 285hp engine designed by Toyota.

Both vehicles got tested by European New Car Assessment Programme (Euro NCAP), with the same number of safety stars gained in the process. Moving further on, let's take a closer look at some additional safety-related facts. Both vehicles belong to the luxury car segment, which is generally a very good thing safety-wise, but that fact doesn't break the tie between the two cars. Furthermore, taking kerb weight as an important factor into account, the German car offers a marginal difference of 7% more metal.

Reliability is not the best thing to consider on the make level, but it is worth mentioning that Lexus as a brand displays somewhat better results, all the models observed together. That's the official data, while our visitors describe reliability of Mercedes Benz with an average rating of 4.4, and models under the Lexus badge with 4.9 out of 5. Independent research findings rank E as average reliability-wise, and GS is more or less at the same level.That apart, owners of different cars powered by the same engine as the German car rank it on average as 5.0 out of 5, exactly the same as the other one.

Mercedes Benz is a bit more agile, reaching 100km/h in 0.6 seconds less than its competitor. Still, it lacks the power to win the top speed competition, topping at 250 kilometers per hour, exactly the same as the other car does. When it comes to fuel economy things look pretty much the same for both cars, averaging around 11.7 liters of fuel per 100 kilometers (24 mpg), in combined cycle.

Lexus appears just a bit more reliable, although the difference is truly marginal. The most important thing when deciding between any two vehicles should always be safety, both passive and active. In my opinion, everything taken into account, the German car offers slightly better overall protection and takes the lead. It all continues in the same direction, with Mercedes Benz offering somewhat better performance, just enough to call it quicker. It does come at a cost though, and that's the fuel consumption... It's really tough to make a final decision here, but if I'd need to, I'd say Lexus. Nevertheless, let's not forget that people have different preferences and needs, so what really counts is your personal feel. I'm only here to help. I suggest you spend two more minutes in order to find out which car, based on your needs and budget, would be picked by the virtual adviser™, out of 12.000+ vehicles we currently have in our database.