Two significantly similar cars, no doubt about that. Still, each one has something different to offer. Having both cars powered by petrol engines and utilizing the 4-door sedan body style within the same 'Luxury car' segment, the only major difference here really is their wheel drive configuration (4 x 4 for the Mercedes Benz and rear in the case of the Lexus). The first one has a Mercedes Benz-engineered powertrain under the hood, a 6-cylinder, 24-valves 272hp unit, while the other one gets its power and torque from a 6-cylinder, 24-valves 252hp engine designed by Toyota.

Both vehicles got tested by European New Car Assessment Programme (Euro NCAP), with the same number of safety stars gained in the process. That aside, let's consider some other aspects which affect safety. Both vehicles belong to the luxury car segment, which is generally a very good thing safety-wise, but that fact doesn't break the tie between the two cars. Furthermore, taking kerb weight as an important factor into account, the German car offers a marginal difference of 6% more metal.

I don't like generalizing things when it comes to reliability, although it does seem that Lexus as a brand displays somewhat better results, when all the models are taken into account. These are the results of an independent reasearch, while our visitors describe reliability of Mercedes Benz with an average rating of 4.4, and models under the Lexus badge with 4.9 out of 5. Some independent research have also placed E as average reliability-wise, and GS is more or less at the same level.Above it all, drivers of cars with the same engine as the German car rank it on average as 5.0 out of 5, exactly the same as the other one.

Mercedes Benz is a bit more agile, reaching 100km/h in 0.1 seconds less than its competitor. In addition to that it accelerates all the way to 250 kilometers per hour, 10km/h more than the other car. When it comes to fuel economy things look pretty much the same for both cars, averaging around 10.1 liters of fuel per 100 kilometers (28 mpg), in combined cycle.

Lexus appears just a bit more reliable, although the difference is truly marginal. The most important thing when deciding between any two vehicles should always be safety, both passive and active. In my opinion, everything taken into account, the German car offers slightly better overall protection and takes the lead. It all continues in the same direction, with Mercedes Benz offering somewhat better performance, just enough to call it quicker. It does come at a cost though, and that's the fuel consumption... It's really tough to make a final decision here, but if I'd need to, I'd say Lexus. Nevertheless, let's not forget that people have different preferences and needs, so what really counts is your personal feel. I'm only here to help. Also, you could use the oportunity to find out which car, everything taken into account, would be the perfect choice for you in the eyes of the virtual adviser™, out of 12.000+ vehicles we currently have in our database.