Two significantly similar cars, no doubt about that. Still, each one has something different to offer. Having both cars powered by petrol engines and utilizing the 4-door sedan body style within the same 'Large family car' segment, the only major difference here really is their wheel drive configuration (4 x 4 for the Mercedes Benz and rear in the case of the Lexus). The first one has a Mercedes Benz-engineered powertrain under the hood, a 6-cylinder, 24-valves 231hp unit, while the other one gets its power and torque from a 6-cylinder, 24-valves 207hp engine designed by Toyota.

The first thing to look into here would be the results from European New Car Assessment Programme (Euro NCAP) tests performed on the two cars. Good thing is that both vehicles got tested, with the same number of safety stars gained in the process. That aside, let's consider some other aspects which affect safety. Both vehicles belong to the large family car segment, which is generally a good thing safety-wise, but it doesn't do much to help us decide between the two. Furthermore, when it comes to weight, a factor that most people underestimate, the Japanese car offers a marginal difference of 1% more metal.

Reliability is not the best thing to consider on the make level, but it is worth mentioning that Lexus as a brand displays somewhat better results, at least on all of the models level. These are the results of an independent reasearch, while our visitors describe reliability of Mercedes Benz with an average rating of 4.4, and models under the Lexus badge with 4.9 out of 5. Some independent research have also placed C as average reliability-wise, and IS is more or less at the same level.We should definitely mention that owners of cars with the same powertrain as the German car rank it on average as 4.0, while the one under the competitor's bonnet gets 5.0 out of 5.

Mercedes Benz is a bit more agile, reaching 100km/h in 0.8 seconds less than its competitor. In addition to that it accelerates all the way to 243 kilometers per hour, 13km/h more than the other car. When it comes to fuel economy things look pretty much the same for both cars, averaging around 9.6 liters of fuel per 100 kilometers (29 mpg), in combined cycle.

Lexus appears just a bit more reliable, although the difference is truly marginal. The most important thing when deciding between any two vehicles should always be safety, both passive and active. In my opinion, everything taken into account, the Japanese car offers slightly better overall protection and takes the lead. From there things take a different direction, with Mercedes Benz offering somewhat better performance, just enough to call it quicker. To make things even better, it consumps less fuel! It's really tough to make a final decision here, but if I'd need to, I'd say Mercedes Benz. Nevertheless, let's not forget that people have different preferences and needs, so what really counts is your personal feel. I'm only here to help. Also, you could use the oportunity to find out which car, everything taken into account, would be the perfect choice for you in the eyes of the virtual adviser™, out of 12.000+ vehicles we currently have in our database.